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. 2020 Dec 10;10:21708. doi: 10.1038/s41598-020-78776-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential expression of human HSC activation during the initiation stage. (A) Volcano plot of the comparison between the freshly isolated, quiescent HSC (day 0, n = 4) and day 3 HSC (initiation of activation, day 3, n = 4). In blue—differentially under-expressed miRNA in day 0; in red—differentially over-expressed miRNA in day 0 (p-adjusted < 0.05 and foldchange > 1). (B) Heatmap of the 20 significantly under-expressed miRNA in day 0 when compared to day 3, p-adjusted < 0.05. (C) Heatmap of the 84 significantly over-expressed miRNA in day 0 when compared to day 3, p-adjusted < 0.05. (D) and (E) Biological networks of differentially expressed miRNA. In blue and red, under and over-expressed miRNA, respectively. Shadowed in grey are molecules related to miRNA, as displayed on the legend. Lines represent different relationships between the molecules and miRNA.