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. 2020 Dec 10;10:21708. doi: 10.1038/s41598-020-78776-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Significantly different miRNA with the same directionality of expression change in both rat and human species. (A) Heatmaps of the significantly changed miRNA during the initiation stage of HSC activation in rat (left) and human (right). (B) Heatmaps of the significantly changed miRNA during the perpetuation stage in rat (left) and human (right). (C) Venn diagram showing the number of significantly upregulated (left) or downregulated (right) miRs during the initiation stage of HSC activation in rat and human. (D) Venn diagram showing the number of significantly upregulated (left) or downregulated (right) miRs during the perpetuation/full activation stage of HSC activation in rat and human. (E) Biological network of significantly differentially expressed miRNA with the same directionality in both species during the early stages of HSC activation. In blue and red, under and over-expressed miRNA, respectively. Shadowed in grey are molecules related to miRNA, as displayed on the legend. Lines represent different relationships between the molecules and miRNA. (F) Biological network of significantly differentially expressed miRNA with the same directionality in both species during the perpetuation of HSC activation. In blue and red, under and over-expressed miRNA, respectively. Shadowed in grey are molecules related to miRNA, as displayed on the legend. Lines represent different relationships between the molecules and miRNA. Networks were generated using miRNA from the overlapping between rat and human, however I am not sure how to explain in a fig legend).