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. 2020 Dec 10;10:21708. doi: 10.1038/s41598-020-78776-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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miR150 mimic decreases ZEB1, Col1A1 and αSMA expression in rat HSC. (A) miR150-5p expression levels in human HSC (left) and rat HSC (right) as quantified by qPCR (both n = 4). (B) miR150-5p expression levels in miR150 mimic transfected rat HSC as quantified by qPCR. Rat HSC were transfected with miR150 mimic (n = 3), expression levels of ZEB1 (C, left panel), αSMA (D, left panel) and Col1A1 (E, left panel) were quantified by qPCR and immunoblotted (C, right panel, D, right panel and E, right panel, respectively). (F) Serum of patients with advanced fibrosis due to ALD (n = 20) and healthy controls (n = 10) was collected and levels of miR150 quantified by qPCR. Statistical significance determined by Student’s t-test where * denotes p = 0.0168.