Table 6.
IC50 (μM) for 4a–j and 6a–e against the tested cancer cell lines.
Compound | MCF-7 | A549 | HCT-116 |
---|---|---|---|
4a | 14.36 ± 0.87 | 22.36 ± 1.39 | 16.65 ± 1.09 |
4b | 12.57 ± 1.41 | 19.73 ± 2.18 | 13.85 ± 1.44 |
4c | 13.11 ± 2.05 | 22.13 ± 1.58 | 15.49 ± 1.72 |
4d | 14.06 ± 1.13 | 22.95 ± 1.36 | 16.43 ± 2.11 |
4e | 5.76 ± 1.53 | 10.45 ± 1.04 | 15.67 ± 1.68 |
4f | 5.42 ± 1.40 | 10.23 ± 1.77 | 16.88 ± 0.85 |
4g | 6.31 ± 1.08 | 11.79 ± 1.82 | 16.09 ± 1.67 |
4h | 7.95 ± 1.95 | 7.82 ± 1.66 | 13.94 ± 1.18 |
4i | 13.07 ± 1.64 | 14.55 ± 1.62 | 18.16 ± 1.30 |
4j | 10.63 ± 1.77 | 12.87 ± 2.03 | 17.39 ± 1.84 |
6a | 20.42 ± 1.39 | 27.48 ± 0.98 | 10.15 ± 0.97 |
6b | 23.55 ± 1.45 | 25.65 ± 1.19 | 9.26 ± 1.51 |
6c | 21.13 ± 1.73 | 24.29 ± 1.50 | 8.22 ± 1.25 |
6d | 22.84 ± 0.97 | 26.56 ± 1.82 | 8.55 ± 1.17 |
6e | 28.65 ± 2.16 | 30.25 ± 1.33 | 13.89 ± 1.48 |
Sorafenib | 5.84 ± 0.87 | 9.63 ± 1.12 | 7.56 ± 1.08 |