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. 2020 Dec 10;10:21629. doi: 10.1038/s41598-020-78410-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SPS induces anxiety-like behavior in the EPM. (a) Time spent in the open arms of the EPM is shown. Exposure to SPS significantly reduced time spent in the open arms (median [IQR]; non SPS: 104.2 [31.1–147.5], SPS: 26.9 [4.0–31.5], Mann–Whitney’s U-test; W = 111, p = 0.023). (b) Number of open-arm entries in the EPM are shown. SPS tended to decrease the number of open-arm entries (median [IQR]; non SPS: 104.7 [58.1–136.0], SPS: 48.4 [14.1–81.5], Mann–Whitney’s U-test; W = 104, p = 0.065). (c) Distance travelled in the OFT is shown. Exposure to SPS did not change distance travelled (median [IQR]; non SPS: 83.6 [64.1–122.9], SPS: 129.2 [71.8–150.2], Mann–Whitney’s U-test; W = 57, p = 0.41). Data are shown using % of controls. Reference control is the (-) group. Data are presented as scatter plots including median and interquartile range. Mann–Whitney’s U-test was performed to compare two groups. n = 12/group. (-): non-SPS group, EPM: elevated plus maze test, OFT: open field test, SPS: single prolonged stress.