Fig. 5.

RNA-seq analyses of Ppara KO mice and fenofibrate-administered mice.

(a) Pie chart showing the distribution of the number of genes that are differentially expressed between WT and Ppara KO mice.

(b) The top five canonical pathways in which the differentially expressed genes (between WT and Ppara KO mice) are enriched were identified using IPA.

(c) Pie chart showing the distribution of the number of genes that are differentially expressed between corn oil- and fenofibrate-administered mice.

(d) The top five canonical pathways in which the differentially expressed genes (between corn oil-and fenofibrate-administered mice) are enriched were identified using IPA.

(e) Venn-diagram (upper panel) showing shared genes among upregulated genes in Ppara KO mice and genes downregulated in fenofibrate-administered mice. Venn-diagram (lower panel) showing shared genes among genes downregulated in Ppara KO mice and genes upregulated in fenofibrate-administered mice.

(f) Top five canonical pathways shared among Ppara KO mice and fenofibrate-administered mice.

(g) Heatmap showing genes differentially expressed in the synaptogenesis signaling pathway.