TABLE 2.
IPA based on 200 high-frequent genes of correctly predicted transcriptomic profiles.
| IPA modules | # Genes | Gene Name | p-value |
| Canonical Pathways | |||
| GADD45 Signaling | 10 | CCNB1, CCND1, CCND3, CDK1, CDK4, CDKN1A, GADD45A, GADD45B, PCNA, TP53 | 2.13E-14 |
| Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 9 | CCNB1, CCNB2, CDK1, CDKN1A, GADD45A, PLK1, RPS6KA1, TOP2A, TP53 | 8.66E-09 |
| Estrogen-mediated S-phase Entry | 7 | CCND1, CDC25A, CDK1, CDK4, CDKN1A, CDKN1B, MYC | 1.16E-08 |
| Cyclins and Cell Cycle Regulation | 10 | CCNB1, CCNB2, CCND1, CCND3, CDC25A, CDK1, CDK4, CDKN1A, CDKN1B, TP53 | 2.12E-08 |
| ATM Signaling | 10 | ATF1, CCNB1, CCNB2, CDC25A, CDK1, CDKN1A, GADD45A, GADD45B, NFKBIA, TP53 | 2.94E-08 |
| Hepatoxicity-related Functions | |||
| Liver Cancer | 46 | ATF5, BIRC5, C2CD5, CANT1, CCDC92, CCNB1, CCNB2, CCND3, CDC45, CGRRF1, CNDP2, CYTH1, DDIT4, DUSP4, GRB10, HMGCS1, HMOX1, HSPA8, HSPD1, IFRD2, IGFBP3, INPP1, INSIG1, JADE2, KEAP1, KIF14, LBR, LGMN, LOXL1, LSM5, MYC, NPC1, NR2F6, NRIP1, POLR2I, RELB, SPR, STXBP1, TIAM1, TIPARP, TLE1, TOP2A, TP53, USP1, WASHC4, WDTC1 | 2.26E-01 |
| Hepatoblastoma | 1 | TP53 | 3.06E-02 |
| Gene Ontology Analysis | |||
| Nucleus | 55 | TOP2A, KDM5B, CDKN1B, FHL2, GABPB1, PRSS23, HOXA10, RGS2, ZFP36, CCND3, TUBB6, CCND1, MYC, RPS6KA1, IER3, TSC22D3, IGFBP3, NOSIP, CDC25A, UGDH, NPEPL1, MELK, BIRC5, ATF5, TP53, RBKS, NOTCH1, PCNA, CDCA4, GLRX, ADRB2, FOXO4, RELB, DNAJB1, CCNB2, CCNB1, NFIL3, USP1, HMOX1, SCAND1, WDTC1, SPDEF, HSPA8, XBP1, SPAG7, GADD45B, UBE2C, TIPARP, SORBS3, PSMB8, NR2F6, FOSL1, NFKBIA, NET1, POLE2 | 1.96E-03 |
| Nucleolus | 20 | TOP2A, TCERG1, TLE1, MYO10, PARP2, PLK1, PWP1, ACAT2, JMJD6, CDK4, MYC, NRIP1, RRS1, NUSAP1, TIMELESS, CCDC86, RBM34, POLR2I, RAE1, TP53 | 6.81E-03 |
| Nucleoplasm | 33 | TOP2A, ATF1, RNH1, PCNA, STXBP1, KEAP1, FOXO4, TSEN2, SMC4, CNDP2, GNAI2, RELB, CDC20, CCND1, PUF60, SPR, MYC, EPB41L2, HMG20B, CBR3, PARP2, GADD45A, CGRRF1, CDC25B, JMJD6, CCNA2, UGDH, PLCB3, TNIP1, STUB1, ATF5, DLD, RAD9A | 1.01E-02 |
| Midbody | 7 | PLK1, CDK1, KIF14, KEAP1, BIRC5, KIF20A, GNAI2 | 2.27E-02 |
| Cytoplasm | 52 | KDM5B, RNH1, CASC3, TSEN2, SMC4, CNDP2, HOXA10, CDC20, PCMT1, RGS2, CCND3, TUBB6, PNP, CCND1, SPR, KIF5C, RPS6KA1, NUSAP1, PARP2, TSC22D3, NOSIP, KCTD5, CDC25A, CDC25B, NPEPL1, MELK, BIRC5, ATF5, TP53, RBKS, PCNA, INPP1, PRUNE1, HSPD1, GNAI2, EPB41L2, CYTH1, UBQLN2, MYO10, GADD45B, UBE2C, GADD45A, PLK1, SORBS3, PSMB8, MLLT11, EIF5, GNPDA1, TNIP1, BAMBI, CDK1, RAD9A | 2.27E-02 |
| Spindle Microtubule | 5 | PLK1, NUSAP1, CDK1, BIRC5, AURKA | 2.27E-02 |
| Cyclin-Dependent Protein Kinase Holoenzyme Complex | 4 | CCND3, CDKN1A, CCND1, CDK4 | 3.36E-02 |
| Positive Regulation Of Apoptotic Process | 10 | MLLT11, TOP2A, NET1, NOTCH1, MELK, GADD45B, GADD45A, IGFBP3, HMOX1, SPDEF | 2.75E-02 |