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. 2020 Nov 27;11:587829. doi: 10.3389/fgene.2020.587829

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Copyright © 2020 Zhang, Xiao, Gu, Liu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), G-quartet, and G-quadruplex. (A) The SARS-CoV-2 particle structure is composed of four structural proteins, which are the spike protein, the envelope protein, the membrane protein, and the nucleocapsid protein. The nucleocapsid proteins are bound to the SARS-CoV-2 genome. (B) Structure of G-quartet; the neighboring guanines are connected via Hoogsteen hydrogen. The cation is indicated by a yellow circle. (C) The G-quadruplex is formed by stacking multiple G-quartets, and the stabilization of the structure is partially determined by the central cations.