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LncRNA XLOC_221242 regulates the expression of DNER, which is the key factor of Notch signal pathway. DNER regulates its downstream target RBPJ and SKP1, and also interacts with the important factors of Wnt signaling pathways, CTNNB1 and CDH2, regulating tumor proliferation, differentiation, invasion, migration, and angiogenesis of PanNENs tumorigenesis.
