Table 2.
The mean meta-analysis: gray matter volume reductions in MSA-P patients relative to HCs.
| Regions | No. of voxels | Maximum MNI coordinates (x, y, z) | SDM-Z value | p-value | Egger test (p-value) | Clusters' breakdown | Jackknife sensitivity analysis |
|---|---|---|---|---|---|---|---|
| Area 1 | 3,210 | 32, 14, −6 | −3.425 | ~0 | 0.965 | Right insula Right lenticular nucleus and putamen Right striatum Right rolandic operculum (RO) Right Heschl gyrus Right superior temporal gyrus Right inferior frontal gyrus, opercular part Right amygdala Right temporal pole, superior temporal gyrus |
10 out of 10 10 out of 10 10 out of 10 10 out of 10 8 out of 10 9 out of 10 10 out of 10 10 out of 10 9 out of 10 |
| Area 2 | 1,459 | −34, 6, −4 | −2.908 | <0.0001 | 0.828 | Left insula, Left lenticular nucleus and putamen, Left striatum, Left amygdala |
10 out of 10 10 out of 10 10 out of 10 10 out of 10 |
| Area 3 | 587 | −38, −50, −36 | −2.612 | <0.0001 | 0.010 | Left cerebellar hemispheric lobule VI, Left cerebellar hemispheric lobule VIIB, Left cerebellar hemispheric lobule VIII, Left cerebellar crus I, Left cerebellar crus II |
9 out of 10 8 out of 10 7 out of 10 9 out of 10 8 out of 10 |
| Area 4 | 389 | −18, 10, 10 | −2.519 | 0.0001 | 0.049 | Left caudate nucleus | 10 out of 10 |
MSA-P, multiple system atrophy with predominant parkinsonism; HCs, healthy controls; MNI, Montreal Neurological Institute; SDM, Seed-based d Mapping.