Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 27;8:600350. doi: 10.3389/fcell.2020.600350

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Ye, Sun and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The outcomes of fatty acid and cholesterol metabolism in cancer-associated host cells. (A) In TME, FA metabolism promotes metabolic shift and angiogenesis in EC and LEC, reduces fibrogenesis, and generally induces protumor phenotype in immune cells. (B) In contrast, cholesterol metabolism promotes EC proliferation, induces protumor phenotype in immune cells, and produces contradictory effects in CAFs and cytotoxic T lymphocytes. Of note, several host cell types remain un-investigated. TME, tumor microenvironment; FA, fatty acid; EC, endothelial cell; LEC, lymphatic endothelial cell; CAFs, cancer-associated fibroblasts.