FIGURE 3.

SNX27 overexpression enhanced learning and memory in hSNX27 mice. (A) In the Morris water maze test, WT and Tg mice were evaluated for escape latency over a 4-day training. On the 5th day, percentage of time the mice spent in the target zone and the number of crossings over the platform region were quantified. (B) The object location memory test was conducted to assess the short-term (2 h) memory of WT and Tg mice. (C) In the fear conditioning test, freezing percentage was assessed to evaluate contextual memory 24 h after training. Representative traces are shown. Data represent mean ± s.e.m. (WT, n = 14; and Tg, n = 16). *P < 0.05 (two-tailed unpaired t test).