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. 2020 Nov 27;8:595357. doi: 10.3389/fcell.2020.595357

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Copyright © 2020 Huo, Gao, Zheng, Zhao, Guo, Zhang, Zeng, Cheng, Gu, Zhang, Zhu, Luo, Zhang, Zhou, Zhang, Sun, Xu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of human SNX27 promoted synaptic plasticity in hSNX27 mice. (A) Input–output response generated by stimulating the Schaffer-collateral pathway and recording in CA1 pyramidal neurons. (A, left) Representative traces of eEPSCs and quantitative analysis of eEPSC amplitude against stimulus intensity (A, right). eEPSCs were recorded at a holding potential of –70 mV. n = 6–8 cells per group. (B) Paired-pulse ratio analysis. (B, left) Representative traces of paired eEPSCs. (B, right) Summary of paired-pulse ratio against different time intervals. n = 6–8 cells per group. (A,B) Data represent mean ± s.e.m. *P < 0.05 (repeated measures two-way ANOVA). (C) LTP was induced in the CA3-CA1 synapses. (C, left) Representative traces of fEPSP responses before and after high frequency stimulation (HFS). (C, middle) Time course of LTP are shown for WT and Tg mice; LTP was induced by two trains of 100-Hz stimuli in the Schaffer-collateral pathway. (C, right) Quantitative analysis of fEPSP potentiation was determined at a mean of 50–60 min after high frequency stimulation. n = 5–7 slices per group. Data represent mean ± s.e.m. *P < 0.05, ***P < 0.001 (two-tailed unpaired t test).