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Domain architecture and interaction partners of CCM2 and CCM2L. CCM2 comprises a N-terminal phosphotyrosine binding domain (PTB) domain, a middle LD-like motif and a C-terminal harmonin homology domain (HHD). Smurf1 and KRIT1 binds CCM2's PTB domain, CCM3 binds CCM2's LD-like motif and MEKK3 binds CCM2's HHD. CCM2L comprises a PTB domain and HHD. KRIT1 binds CCM2L's PTB domain and MEKK3 binds CCM2L's HHD.
