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Junctional signalling. KRIT1 forms a complex with Rap1, HEG1 and Rasip1 that is important for their recruitment to and stabilization of endothelial junctions. Rasip1 also binds Radil1 and ARHGAP29 and leads to their recruitment to junctions. This leads to inhibition of Rho activity by ARHGAP29, inhibiting ROCK activation and downstream MLC phosphorylation.
