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. 2020 Nov 27;8:602278. doi: 10.3389/fcell.2020.602278

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Copyright © 2020 Hendriks and Ramasamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Factors affecting vasculature in physiological remodeling of bone. Healthy bone (right) showing columnar type-H vessels in the metaphysis and sinusoidal type-L vessels in the diaphysis. The bone marrow has a strong blood supply and is well-oxygenated, supporting the process of bone remodeling and increasing bone mineral density (BMD). Weak bone (left) showing sinusoidal type-L vessels filling the marrow space, with decreased blood flow and oxygenation. These factors lead to a reduction in hematopoiesis and increased risk of osteoporosis. Arrows (middle) show selected physiological factors known to promote the strong healthy bone state (red) and the weak bone state (blue).