FIGURE 6.

Schematic illustration of a size reducible core-corona nanostructure that was self-assembled by two unimers of conjugated Pluronic P₁₂₃ to DMMA-PEI (PSPD) via disulfide bond and dexamethasone modified Pluronic P₁₂₃ (P₁₂₃-Dex). The core-corona nanostructure efficiently delivered DOX into the nucleus of tumor cells through exploiting acidic pH and intracellular redox potential, as well as the ability of dexamethasone to target and dilate nuclear pores (reproduced with permission from Wang et al. (2017). Copyright 2017 John Wiley and Sons).