TABLE 1.

Aminoacyl-tRNA synthetases (ARSs) as potential biomarkers in cancer.

ARSs	Cancer type	Expression status	Effects	References
AIMP2-DX2	Lung cancer	Upregulation	The ratio of AIMP2-DX2 to AIMP2 was negatively correlated with patient survival.	Choi et al., 2011
EPRS	Breast cancer	Upregulation	Related to poor clinical outcomes in breast cancer.	Qi et al., 2019
SerRS	Breast cancer	Downregulation	High levels of SerRS were tightly correlated with the high relapse-free survival.	Li Y. et al., 2019
NRS	Lung cancer	Upregulation	Positively associated with lymph node metastasis.	Hsu et al., 2016
MRS	Lung cancer	Upregulation	Associated with poor prognosis in NSCLC.	Kim E.Y. et al., 2017
KRS	Lung cancer	Upregulation	Predicted disease-free survival in NSCLC patients.	Boulos et al., 2017
KRS	Colon cancer	Upregulation	Had a good diagnostic value for colorectal cancer.	Suh et al., 2020
TRS	Ovarian cancer	Upregulation	Positively correlated with disease stage and VEGF levels.	Wellman et al., 2014
AIMP3	Bladder cancer	Downregulation	Predicted the overall survival following radiotherapy and disease recurrence in MIBC patients.	Gurung et al., 2015