FIGURE 3.

A novel hydrogel constructed with supramolecular guest–host interaction with three arms covalently crosslinked with GelMA. (A) Photographs showing the HGSM preparation process. (B) The design structure of the HGGelMA before and after crosslinking. (C) Digital images of the GelMA hydrogels that suffered the pressure of a 500 g weight and HGGelMA hydrogel that supported the pressure of a 1 kg weight. (D) Schematic of the mechanism involved in the robust and fatigue-resistant mechanical behavior of the HGGelMA. (E) 3D bioprinting of HGGelMA into scaffolds using HGGelMA precursors as a printing ink. (F,G) 3D rotational microscopy images showing the swelling equilibrium scaffolds under the swelling equilibrium when the scaffolds were constructed through layer-by-layer deposition with an alternating angle of 45° (F) or 90° (G) between adjacent layers and the resultant scaffolds. Adapted with permission from Wang Z. et al. (2019).