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. 2020 Nov 27;8:604814. doi: 10.3389/fbioe.2020.604814

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Copyright © 2020 Dai, Sun, Leng, Hu and Ao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A highly stretchable and tough hydrogels developed by mixing sodium alginate and PEG to constitute an IPN. (A) Schematic diagrams of the biocompatible and tough hydrogel. (B) A printed bilayer mesh is uniaxially stretched to three times of its initial length. (C) A printed pyramid undergoes a compressive strain of 95% while returning to its original shape after relaxation. (D) Various 3D constructs printed with the hydrogel. (E) A mesh printed with the tough and biocompatible hydrogel. The mesh was used to host HEK cells. (F) Live-dead assay of HEK cells in a collagen hydrogel infused into the 3D printed mesh of the PEG–alginate–nanoclay hydrogel. (G) Viability of cells through 7 days. Adapted with permission from Hong et al. (2015a).