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. 2020 Nov 27;8:604814. doi: 10.3389/fbioe.2020.604814

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Copyright © 2020 Dai, Sun, Leng, Hu and Ao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A bioactive nanoengineered hydrogels for tissue engineering. (A) Schematic representation of fabrication of nanocomposite hydrogels. (B) Optical images showing mechanical toughness of the Gel and nanocomposite hydrogels after deformation. (C) Nanocomposite hydrogels were subjected to unconfined compression up to 0.90 strain. (D) Schematic representation of fabrication of nanosilicate-loaded microgels. (E) In the 3D encapsulation of cells in nanocomposite hydrogels, all scaffolds supported cellular viability. (F) The addition of nanosilicate to GelMA results in a shear-thinning characteristic and can be printed to design complex structures. Adapted with permission from Xavier et al. (2015).