Table 1.
Conventional markers of extracellular vesicles.
| Protein family | Accession | Score | Mass | Matches | Sequences | Protein description |
|---|---|---|---|---|---|---|
| Tetraspanins | CD9 | 223 | 25,969 | 20 (9) | 6 (3) | CD9 antigen |
| CD 63 | 111 | 26,474 | 24 (4) | 8 (2) | CD63 antigen | |
| CD 81 | 361 | 26,476 | 6 (6) | 1 (1) | CD81 antigen | |
| Adhersion proteins | CD44 | 521 | 82,001 | 19 (11) | 7 (2) | CD44 antigen |
| ICAM1 | 139 | 58,587 | 17 (5) | 10 (4) | Intercellular adhesion molecule 1 | |
| ITB1 | 874 | 91,664 | 63 (35) | 26 (13) | Integrin beta-1 | |
| ITA1 | 530 | 132,304 | 57 (26) | 33 (15) | Integrin alpha-1 | |
| ITAV | 365 | 117,048 | 46 (18) | 32 (13) | Integrin alpha-V | |
| ITAM | 409 | 128,410 | 40 (16) | 31 (12) | Integrin alpha-M | |
| ITB2 | 264 | 87,976 | 29 (11) | 13 (7) | Integrin beta-2 | |
| ITA5 | 352 | 115,605 | 25 (12) | 16 (10) | Integrin alpha-5 | |
| ITB3 | 312 | 90,194 | 34 (12) | 21 (6) | Integrin beta-3 | |
| ITA6 | 275 | 127,724 | 45 (10) | 31 (8) | Integrin alpha-6 | |
| ITB5 | 148 | 91,303 | 41 (6) | 14 (5) | Integrin beta-5 | |
| ITA2B | 239 | 114,446 | 11 (8) | 9 (6) | Integrin alpha-IIb | |
| ITA3 | 128 | 117,735 | 29 (6) | 23 (5) | Integrin alpha-3 | |
| ITA11 | 103 | 134,527 | 26 (4) | 20 (4) | Integrin alpha-11 | |
| ITA7 | 91 | 130,121 | 20 (3) | 16 (3) | Integrin alpha-7 | |
| ITAL | 79 | 129,942 | 14 (3) | 12 (3) | Integrin alpha-L | |
| ITA2 | 70 | 130,468 | 20 (3) | 14 (3) | Integrin alpha-2 | |
| ITA9 | 28 | 115,727 | 17 (1) | 15 (1) | Integrin alpha-9 | |
| ITA4 | 26 | 116,252 | 20 (1) | 15 (1) | Integrin alpha-4 | |
| ITB4 | 53 | 205,745 | 42 (1) | 30 (1) | Integrin beta-4 | |
| Vesicle trafficking-related proteins | ANXA1 | 2530 | 38,918 | 115 (79) | 31 (19) | Annexin A1 |
| ANXA2 | 4829 | 38,808 | 207 (156) | 40 (27) | Annexin A2 | |
| ANXA3 | 184 | 36,524 | 11 (5) | 11 (5) | Annexin A3 | |
| ANXA4 | 1292 | 36,088 | 78 (41) | 32 (16) | Annexin A4 | |
| ANXA5 | 2201 | 35,971 | 107 (68) | 34 (25) | Annexin A5 | |
| ANXA6 | 4079 | 76,168 | 209 (144) | 68 (45) | Annexin A6 | |
| ANXA7 | 486 | 52,991 | 46 (19) | 26 (12) | Annexin A7 | |
| ARF3 | 651 | 20,645 | 55 (27) | 15 (10) | ADP-ribosylation factor 3 | |
| ARF4 | 564 | 20,612 | 37 (25) | 13 (9) | ADP-ribosylation factor 4 | |
| ARF5 | 486 | 20,631 | 40 (20) | 15 (7) | ADP-ribosylation factor 5 | |
| ARF6 | 233 | 20,183 | 26 (11) | 12 (5) | ADP-ribosylation factor 6 | |
| TSG101 | 45 | 44,088 | 28 (1) | 16 (1) | Tumor susceptibility gene 101 protein | |
| Flotillins | FLOT1 | 357 | 47,554 | 45 (11) | 26 (8) | Flotillin-1 |
| FLOT2 | 478 | 47,434 | 39 (17) | 21 (11) | Flotillin-2 |