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. 2020 Dec 11;5:290. doi: 10.1038/s41392-020-00417-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Summary of the drug repurposing strategy and the results obtained. a Schema of the procedure followed for finding drug targets that affect the COVID-19 disease map. b Two different patterns of circuits affected by six drugs (see text). c Radar plot representing the impact of the most relevant drugs listed in Supplementary Table S3 over the different COVID-19 hallmarks, quantified as the number of circuits of the corresponding hallmark are potentially affected