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. 2020 Nov 27;10:574277. doi: 10.3389/fonc.2020.574277

Figure 3.

Figure 3

JWH133-induced M2 microglia promotes angiogenesis via increasing the expression of CYP2J2/11,12-EET. (A) Relative CYP2J2 mRNA level (% of Control level) in the Control and JWH133 groups. (B) 11,12-EET content (ng/ml) for Control shRNA, CYP2J2 shRNA, JWH133 + Control shRNA, and JWH133 + CYP2J2 shRNA groups. (C) Representative images of tube formation of HBMECs in groups of Control and 11,12-EET. Scale bar: 200 μm. (D, E) Quantitative data of number of tubes (D, per mm2) and branches (E, per mm2) in HBMECs in the Control and 11,12-EET groups. Data are presented as mean ± S.E.M, n = 5; **P < 0.01 indicates significant differences vs. the Control group; ##P < 0.01 indicates significant differences vs. the JWH133 group (one-way ANOVA followed by Tukey’s post hoc test).