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Time-kill curve study of 2a (A), 1a (B), and 1b (C) versus MRSA in log-phase at drug exposure. The curve displays the mean CFU for duplicate samples and represents data from two independent experiments. Twelve doubling dilutions are plotted, the highest concentration (black line) corresponds to 16 × MIC. Growth in absence of antimicrobial is drawn in red. The compound was added at time point 0 and monitored until 24 h. The limit of detection in the assay was 100 CFU mL–1.
