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. 2020 Nov 27;11:551189. doi: 10.3389/fmicb.2020.551189

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Copyright © 2020 Dinarvand, Spain and Vafaee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-kill curve study of combinations of vancomycin and 2a versus MRSA at drug exposure in MIC concentrations. The curve displays the mean CFU for duplicate samples and represents data from two independent experiments. Twelve doubling dilutions are plotted, the highest concentration (black line) corresponds to 16 × MIC. Growth in absence of antimicrobial is drawn in red. The compound was added at time point 0 and monitored until 24 h. The limit of detection in the assay was 100 CFU mL^–1.