TABLE 2.
Synthetic compound | MIC (μM)†,‡ |
|||
MRSA | M. tuberculosis | E. coli | P. aeruginosa | |
1a | 12.5 ± 1.0 | 1.5 ± 3.0 | 12.5 ± 5.0 | 6.2 ± 9.0 |
1b | 100 ± 5.4 | 25 ± 1.0 | 100 ± 1.0 | 100 ± 6.5 |
2a | 12.5 ± 0.7 | 1.5 ± 1.0 | 50 ± 1.0 | 50 ± 1.0 |
3 | 12.5 ± 1.0 | 3.1 ± 0.7 | 6.2 ± 1.0 | 3.1 ± 5.0 |
13 | 12.5 ± 2.7 | 0.02 ± 1.1 | 25 ± 2.0 | 25 ± 4.0 |
18 | 12.5 ± 2.0 | 12.5 ± 1.0 | 1.5 ± 4.0 | 12.5 ± 0.8 |
†Samples were diluted from 100 to 0.0002 μM and incubated with bacteria (starting concentration OD600 = 0.001) under optimum assay conditions as described in the Experimental section. ‡Values represent averages from three independent repeats.