TABLE 5.
Structure name | Compound alone MIC50 (μM) for M. tuberculosis | Compound MIC50 for M. tuberculosis in presence of Rif (0.25 nM) | FIC | Drug–drug interactions |
1a | 1.5 | 1.5 | 1.1 | Indifference |
1b | 6.25 | 6.25 | 1.1 | Indifference |
2a | 1.5 | 1.5 | 1.1 | Indifference |
3 | 1.5 | 0.38 | 0.4 | Synergy |
13 | 0.02 | 0.02 | 1.1 | Indifference |
18 | 6.25 | 3.13 | 1 | Indifference |