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. 2020 Nov 27;11:551189. doi: 10.3389/fmicb.2020.551189

TABLE 5.

Summary of the checkerboard study between rifampicin and synthetic compounds.

Structure name Compound alone MIC50 (μM) for M. tuberculosis Compound MIC50 for M. tuberculosis in presence of Rif (0.25 nM) FIC Drug–drug interactions
1a 1.5 1.5 1.1 Indifference
1b 6.25 6.25 1.1 Indifference
2a 1.5 1.5 1.1 Indifference
3 1.5 0.38 0.4 Synergy
13 0.02 0.02 1.1 Indifference
18 6.25 3.13 1 Indifference