. Author manuscript; available in PMC: 2021 Dec 1.

Published in final edited form as: Ann Neurol. 2020 Oct 9;88(6):1165–1177. doi: 10.1002/ana.25905

TABLE 3.

Regional Associations of White Matter Hyperintensity and Amyloid Biomarkers with Demographic Features and Diagnostic Groups

Feature/Group	Frontal White Matter Hyperintensity Volume	Temporal White Matter Hyperintensity Volume	Parietal White Matter Hyperintensity Volume	Occipital White Matter Hyperintensity Volume	Striatal Amyloid SUVR	Striatal Amyloid SUVR with Partial Volume Correction
Age	0.07 [0.03, 0.11] p = 0.006^a	0.01 [−6E-3, 0.03] p = 0.43	0.02 [4E-4, 0.04] p = 0.02^a	0.05 [0.03, 0.07] p = 0.001^a	0.01 [2E-3, 0.02] p = 0.06	0.01 [2E-4, 0.02] p = 0.008^a
Age (cognitively stable only)	0.07 [0.01, 0.13] p = 0.02^a	0.01 [−6E-3, 0.03] p = 0.43	0.02 [4E-4, 0.04] p = 0.14	0.04 [1E-3, 0.08] p = 0.04^a	−1E-3 [−0.02, 0.02] p = 0.85	2E-3 [−0.01, 0.01] p = 0.66
Sex (F > M)	−0.31 [−1.0, 0.38] p = 0.39	−0.13 [−0.37, 0.11] p = 0.30	−0.12 [−0.41, 0.17] p = 0.41	−0.54 [−0.95, −0.13] p = 0.01^a	−0.06 [−0.18, 0.06] p = 0.28	−0.09 [−0.23, 0.05] p = 0.22
APOE-ε4 (carrier > noncarrier)	0.32 [−0.52, 1.2] p = 0.46	0.34 [0.07, 0.61] p = 0.02^a	0.30 [−0.05, 0.65] p = 0.09	0.16 [−0.33, 0.65] p = 0.54	0.09 [−0.05, 0.23] p = 0.17	0.13 [−0.03, 0.29] p = 0.09
Diagnosis	1.1 [0.24, 2.0] p = 0.01^a	0.39 [0.08, 0.70] p = 0.01^a	0.82 [0.47, 1.2] p = 2E-5^a	0.44 [−0.11, 0.99] p = 0.11	0.20 [0.06, 0.34] p = 0.005^a	0.23 [0.07, 0.39] p = 0.004^a
Diagnosis, adjusted for age	0.90 [−2E-3, 1.8] p = 0.06	0.40 [0.08, 0.72] p = 0.01^a	0.76 [0.39, 1.1] p = 9E-5^a	0.25 [−0.48, 0.98] p = 0.37	0.19 [0.05, 0.33] p = 0.007^a	0.22 [0.06, 0.38] p = 0.008^a

Each row represents a separate model. Parameters represent unstandardized, mean differences, or odds ratios and their 95% confidence intervals.

Significant at p < 0.05.

F = female; M = male; SUVR = standard uptake value ratio.