Table 7.

Allele frequencies for relevant genetic variants associated with PCOS treatment response in human populations worldwide.

Gene	Reference SNP	Discovery cohort	Consequence	WT > M	Human Populations
					Caucasians		Latin American		Asian		African
IRS-1	rs1801278 (Gly971Arg)	NS	Missense mutation	C > G,T*	Finland	0.06	Colombia	0.03	China	0.01	Barbados	0.07
					Great Britain	0.04	Mexico	0.02	Japan	0.05	USA	0.06
					Spain	0.15	Peru	0.02	Vietnam	0.01	Gambia	0.04
					Italia	0.08	Puerto Rico	0.05	Bangladesh	0.05	Nigeria	0.11
STK11	rs8111699	Caucasian	Intron mutation	C* > G	Finland	0.50	Colombia	0.45	China	0.01	Barbados	0.32
					Great Britain	0.51	Mexico	0.58	Japan	0.01	USA	0.42
					Spain	0.55	Peru	0.39	Vietnam	0.01	Gambia	0.27
					Italia	0.51	Puerto Rico	0.49	Bangladesh	0.33	Nigeria	0.44
SLC22A1	rs12208357 (Arg61Cys)	Caucasian	Missense mutation	C > T*	Finland	0.06	Colombia	0.04	China	0.00	Barbados	0.02
					Great Britain	0.06	Mexico	0.02	Japan	0.00	USA	0.02
					Spain	0.05	Peru	0.01	Vietnam	0.00	Gambia	0.00
					Italia	0.06	Puerto Rico	0.02	Bangladesh	0.02	Nigeria	0.00
SLC22A1	rs34130495 (Gly401Ser)	Caucasian	Missense mutation	G > A*	Finland	0.02	Colombia	0.01	China	0.00	Barbados	0.01
					Great Britain	0.02	Mexico	0.01	Japan	0.00	USA	0.02
					Spain	0.03	Peru	0.01	Vietnam	0.00	Gambia	0.00
					Italia	0.02	Puerto Rico	0.01	Bangladesh	0.01	Nigeria	0.00
SLC22A1	rs34059508 (Gly465Arg)	Caucasian	Missense mutation	G > A*,C	Finland	0.01	Colombia	0.02	China	0.00	Barbados	0.00
					Great Britain	0.04	Mexico	0.04	Japan	0.00	USA	0.00
					Spain	0.02	Peru	0.02	Vietnam	0.00	Gambia	0.00
					Italia	0.01	Puerto Rico	0.01	Bangladesh	0.00	Nigeria	0.00
SLC22A1	rs72552763	Caucasian	Inframe deletion	ATGAT > AT*	Finland	0.16	Colombia	0.27	China	0.01	Barbados	0.06
					Great Britain	0.21	Mexico	0.37	Japan	0.00	USA	0.07
					Spain	0.16	Peru	0.38	Vietnam	0.02	Gambia	0.03
					Italia	0.20	Puerto Rico	0.18	Bangladesh	0.12	Nigeria	0.03
SLC22A1	rs683369 (Leu160Phe)	Asian	Missense mutation	C > A, G*,T	Finland	0.19	Colombia	0.19	China	0.12	Barbados	0.04
					Great Britain	0.23	Mexico	0.05	Japan	0.13	USA	0.05
					Spain	0.24	Peru	0.04	Vietnam	0.14	Gambia	0.00
					Italia	0.17	Puerto Rico	0.13	Bangladesh	0.15	Nigeria	0.00
SLC22A1	rs628031 (Met408Val)	Asian	Missense mutation	G > A*,C	Finland	0.49	Colombia	0.35	China	0.22	Barbados	0.23
					Great Britain	0.39	Mexico	0.12	Japan	0.19	USA	0.29
					Spain	0.43	Peru	0.10	Vietnam	0.25	Gambia	0.32
					Italia	0.34	Puerto Rico	0.26	Bangladesh	0.39	Nigeria	0.23
FSHR	rs6166 (Ser680Asn)	Caucasian	Missense mutation	T > C*	Finland	0.50	Colombia	0.44	China	0.30	Barbados	0.37
					Great Britain	0.44	Mexico	0.34	Japan	0.34	USA	0.43
					Spain	0.43	Peru	0.41	Vietnam	0.32	Gambia	0.35
					Italia	0.46	Puerto Rico	0.48	Bangladesh	0.36	Nigeria	0.48
FSHR	rs6165 (Ala307Thr)	Caucasian	Missense mutation	C > G,T*	Finland	0.50	Colombia	0.56	China	0.67	Barbados	0.26
					Great Britain	0.56	Mexico	0.67	Japan	0.64	USA	0.38
					Spain	0.57	Peru	0.66	Vietnam	0.65	Gambia	0.20
					Italia	0.53	Puerto Rico	0.48	Bangladesh	0.63	Nigeria	0.23

^aFrequency of the minor allele marker with *, NS, not stated; WT, wild type; M, mutant allele.