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. 2020 Nov;8(22):1521. doi: 10.21037/atm-20-7144

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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PPI network construction. (A) PPI network of all DEGs. Yellow and blue nodes represent upregulated and downregulated DEGs, respectively. (B) The top five modules extracted by MCODE. Square and round shapes represent downregulated and upregulated DEGs, respectively. The different colors represent five different Mcode_clusters: cluster 1, red; cluster 2, orange; cluster 3, green; cluster 4, purple; and cluster 5, blue. PPI, protein-protein interaction; DEGs, differentially expressed genes.