Table 1. Clinicopathologic characteristics of patients with primary OTSCC in the TCGA database.
| Characteristic | Subtype | No. of cases (%) | CA9 expression | P value | |
|---|---|---|---|---|---|
| Low | High | ||||
| Age (years) | <60 | 66 (52.8) | 34 | 32 | 0.794 |
| ≥60 | 59 (47.2) | 29 | 30 | ||
| Sex | Male | 81 (64.8) | 40 | 41 | 0.760 |
| Female | 44 (35.2) | 23 | 21 | ||
| Smoking history | Never | 45 (36.0) | 21 | 24 | 0.674 |
| Ever | 77 (61.6) | 39 | 38 | ||
| Unknown | 3 (2.4) | ||||
| Alcohol use | No | 41 (32.8) | 20 | 21 | 0.850 |
| Yes | 83 (66.4) | 42 | 41 | ||
| Unknown | 1 (0.8) | ||||
| Tumor histologic grade | G1 | 16 (12.8) | 10 | 6 | 0.304 |
| G2 + G3 | 109 (87.2) | 53 | 56 | ||
| Clinical stage | I + II | 45 (36.0) | 25 | 20 | 0.319 |
| III + IV | 76 (60.8) | 34 | 42 | ||
| Unknown | 4 (3.2) | ||||
| Clinical N stage | N0 | 63 (50.4) | 31 | 32 | 0.993 |
| N1 + N2 | 57 (45.6) | 28 | 29 | ||
| Unknown | 5 (4.0) | ||||
| Clinical T-stage | T1 + T2 | 50 (40.0) | 27 | 23 | 0.419 |
| T3 + T4 | 71 (56.8) | 33 | 38 | ||
| Unknown | 4 (3.2) | ||||
| Pathologic stage | I + II | 36 (28.8) | 22 | 14 | 0.109 |
| III + IV | 78 (62.4) | 35 | 43 | ||
| Unknown | 11 (8.8) | ||||
| Pathologic N stage | N0 | 50 (40.0) | 28 | 22 | 0.222 |
| N1 + N2 | 61 (48.8) | 27 | 34 | ||
| Unknown | 14 (11.2) | ||||
| Pathologic T-stage | T1 + T2 | 66 (52.8) | 39 | 27 | 0.033* |
| T3 + T4 | 51 (40.8) | 20 | 31 | ||
| Unknown | 8 (6.4) | ||||
| Radiation therapy | No | 40 (32.0) | 23 | 17 | 0.375 |
| Yes | 52 (41.6) | 25 | 27 | ||
| Unknown | 33 (26.4) | ||||
| Targeted molecular therapy | No | 56 (44.8) | 33 | 23 | 0.215 |
| Yes | 23 (18.4) | 10 | 13 | ||
| Unknown | 46 (36.8) | ||||
*, P value <0.05. OTSCC, oral tongue squamous cell carcinoma; TCGA, The Cancer Genome Atlas; CA9, carbonic anhydrase 9.