Table 2. Comparison of CIBERSORT-selected immune cell fractions between tumor and non-tumor tissues from HCC patients.
Immune cell type | CIBERSORT fraction in % of all infiltrating immune cells (mean ± SD) | ||
---|---|---|---|
Tumors (n=8) | Non-tumors (n=7) | P value | |
T cells CD8 | 0.164±0.066 | 0.198±0.080 | 0.422 |
T cells CD4 naive | 0.0±0.0 | 0.0±0.0 | 1.0 |
T cells CD4 memory resting | 0.043±0.065 | 0.058±0.047 | 0.64 |
T cells CD4 memory activated | 0.005±0.011 | 0.001±0.002 | 0.372 |
T cells follicular helper | 0.069±0.033 | 0.077±0.031 | 0.675 |
T cells regulatory (Tregs) | 0.052±0.035 | 0.008±0.009 | 0.007 |
T cells gamma delta | 0.007±0.011 | 0.020±0.019 | 0.152 |
B cells naive | 0.018±0.018 | 0.023±0.030 | 0.479 |
B cells memory | 0.017±0.028 | 0.0±0.001 | 0.132 |
Plasma cells | 0.069±0.031 | 0.064±0.028 | 0.759 |
NK cells resting | 0.005±0.012 | 0.002±0.004 | 0.578 |
NK cells activated | 0.042±0.027 | 0.015±0.019 | 0.05 |
Macrophages M0 | 0.047±0.049 | 0.0±0.0 | 0.025 |
Macrophages M1 | 0.104±0.029 | 0.094±0.039 | 0.605 |
Macrophages M2 | 0.126±0.053 | 0.155±0.050 | 0.326 |
Monocytes | 0.031±0.028 | 0.055±0.033 | 0.184 |
Dendritic cells resting | 0.082±0.065 | 0.035±0.019 | 0.09 |
Dendritic cells activated | 0.003±0.006 | 0.0±0.001 | 0.31 |
Mast cells resting | 0.0±0.0 | 0.002±0.004 | 0.369 |
Mast cells activated | 0.093±0.059 | 0.154±0.183 | 0.444 |
Eosinophils | 0.0±0.0 | 0.0±0.0 | 1.0 |
Neutrophils | 0.021±0.010 | 0.032±0.012 | 0.097 |
Italic P values indicate significance between individual groups. HCC, hepatocellular carcinoma.