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. 2020 Nov;8(22):1514. doi: 10.21037/atm-20-7041

Figure 5.

Figure 5

Changes in the expression and secretion of CysC after mechanical stretch stimulation of rat primary cardiomyocytes and cardiac fibroblasts. (A) ERK phosphorylation after mechanical stretch of primary cardiomyocytes; (B) gene expression of Nppa, Nppb, and Myh7 of primary cardiomyocytes after mechanical stretch; (C) intracellular CysC (Cell-CysC) and secreted CysC in the culture supernatant (SP-CysC) after mechanical stretch of primary cardiomyocytes; (D) expression level of CST3 gene after mechanical stretch of primary cardiomyocytes; (E) intracellular CysC and secreted CysC in the culture supernatant after mechanical stretch of fibroblasts; (F) expression level of CST3 gene after mechanical stretch of fibroblasts (*, P<0.05; **, P<0.01). ERK, extracellular regulated protein kinase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; CysC, cystatin C; SP, supernatant.