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. 2020 Dec 5;21(23):9281. doi: 10.3390/ijms21239281

Figure 1.

Figure 1

Dose-effect and time-course of guanosine (GUO)-mediated anxiolytic-like effect evaluated by elevated plus maze (EPM) test during a 5 min session. Dose-effect (GUO 45 min): (A) number of open arm entries [F(3,44) = 3.929, p < 0.02]; (B) time spent in open arms [F(3,44) = 4.441, p < 0.01]; (C) ratio time in open arms and total time in arms [F(3,44) = 6.939, p < 0.001]. (D–F) Time-course (30 mg/kg GUO): (D) number of open arm entries [F(4,51) = 6.710, p < 0.0005]; (E) time spent in open arms [F(4,51) = 7.672, p < 0.0001]; (F) ratio time in open arms and total time in arms [F(4,51) = 6.148, p < 0.0005]. Ctrl: Control group. Each bar represents the mean value ± SD. Tukey test: * p < 0.05, ** p < 0.01, *** p < 0.001. Ctrl raw mean values: (A) 6.75; (B) 60.05 s; (C) 0.27; (D) 8.58; (E) 95.84 s; (F) 0.45.