5-FU	5-fluorouracil
advCRC	advanced CRC
CI	confidence interval
CR	complete response
CRC	colorectal cancer
ECOG	Eastern Cooperative Oncology Group
EGFR	epidermal growth receptor
FOLFIRI	LV/5-FU/ irinotecan
FOLFIRINOX	LV/5-FU/ irinotecan/oxaliplatin
FOLFOX	LV/5-FU/ oxaliplatin
FOLFOXIRI	LV/5-FU/ oxaliplatin/ irinotecan
HR	hazard ratio
ITT	intention to treat
KRAS	Kirsten rat sarcoma
LV	leucovorin
MAPK	mitogen-activated protein kinases
mCRC	metastatic colorectal cancer
mFOLFOXIRI	modified FOLFOXIRI
MMR	DNA mismatch repair
MSI	microsatellite instable
MSI-H	microsatellite instable-high
MSS	microsatellite stable
NRAS	neuroblastoma N-Ras
ORR	overall response rate
OS	overall survival
PD	progressive disease
PD-1	programmed cell death-1
PD-L1	programmed death ligand-1
PR	partial response
PKB	protein kinase B
PFS	progression-free survival
PI3K	phosphatidylinositol 3-kinase
recCRC	recurrent CRC
RFS	recurrence-free survival
RR	response rate
RTK	receptor tyrosine kinase
S100A4	S100 calcium-binding protein A4
TGF-β	transforming growth factor beta
TTR	time to recurrence
VEGF	vascular endothelial growth factor
Wnt	Wingless-related integration site