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. 2020 Nov 27;25(23):5591. doi: 10.3390/molecules25235591

Figure 2.

Figure 2

AGE–RAGE interaction in immune-related cells transduces signals for gene expressions of proinflammatory and profibrotic cytokines, and increased oxidative stress to induce cell and tissue damage. ISRE: interferon stimulated response element; ROS: reactive oxygen species; RNI: reactive nitrogen intermediates.