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A schematic model illustrating an effect of PEA on CORT-induced depression-like mice model. PEA activates BDNF/Trk-B signaling, leading to the upregulation of excitatory synaptic function in CORT-induced mice. Activation of BDNF/Trk-B signaling rescues abnormal synaptic architecture and behaviors in CORT-induced depression-like mice.
