Table 3.

Antiproliferative activity of the target compounds 3b, 3c, 3e, 8a–d, 9, Dinaciclib, and the control.

Compound	Cytotoxicity IC50 (µM) a ± SEM
3b	9.11 ± 0.39 ***
3c	0.81 ± 0.03 ***
3e	4.18 ± 0.18 ***
8a	26.5 ± 1.13 **
8b	21.5 ± 0.92 **
8c	30.8 ± 1.32 **
8d	87.3 ± 3.73 *
9	12.1 ± 0.52 ***
Dinaciclib	5.97 ± 0.25 ***
Control	0

^a IC₅₀ = compound concentration required to inhibit tumor cell proliferation by 50%. All data were obtained by triplet testing data are expressed as the mean ± SEM from the dose-response curves of at lowest three independent experiments. Results were significantly different from the control at *** p < 0.05. Results indicating at *, ** means less significant.