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. 2020 Dec 11;8:75. doi: 10.1186/s40635-020-00361-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Leukocytes from COVID19 + ICU patients have a unique transcriptional profile compared to leukocytes from COVID19- ICU patients. a Principal component analysis (PCA) plot of total leucocyte (buffy coat) RNA samples derived from COVID19-positive (COVID +) and negative (COVID−) patients after removing the batch effect of date and interaction between date and status, using all principal components and features contributing equally. b Volcano plot of 1311 genes (highlighted) differentially expressed between leucocyte RNA samples derived from COVID19 positive (COVID +) versus negative (COVID−) samples based on a filtering criterion of ± 1.5-Fold change and an FDR step-up p-value cut-off ≤ 0.0545. c Heat map of 1311 genes that were differentially expressed between leucocyte RNA samples derived from COVID19 positive (COVID +) versus negative (COVID−) samples using average linkage, Euclidean distance metric and standardize normalization mode (shift mean to 0 and scale standard deviation to 1 on all features)