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. 2020 Nov 26;21(23):8981. doi: 10.3390/ijms21238981

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Colocalization of GLUT4 and Rab14 in cross-section muscle fibers of rat soleus. In the cross-section muscle fibers of rat soleus treated with the therapy of olive leaf (TOL) in a dose-dependent manner, fibers are present that express Rab14. DAPI was used to stain nuclei (blue). Images (A–E) show magnification 1000X. Scale bars indicate 20 μm. (a) Representative immunofluorescent pictures show the relationship between Rab14 and GLUT4 muscle fibers in Wistar rats: (a(A1–A4)) untreated; (a(B1–B4)) with SZT-induced diabetes; (a(C1–C4)) with SZT-induced diabetes and treated with TOL1, (a(D1–D4)) with TOL2, and (a(E1–E4)) with TOL3. (b) GLUT-Rab14 colocalization was assessed in the area of interest (0.014 mm²/4 μm slice × 3 slices/rat × 6 rats/group) by calculating the Pearson correlation coefficient using the JACoP plugin on ImageJ. Values are expressed as mean ± SD. One-way ANOVA followed by the post hoc Scheffé test: ** p < 0.01.

Colocalization of GLUT4 and Rab14 in cross-section muscle fibers of rat soleus. In the cross-section muscle fibers of rat soleus treated with the therapy of olive leaf (TOL) in a dose-dependent manner, fibers are present that express Rab14. DAPI was used to stain nuclei (blue). Images (A–E) show magnification 1000X. Scale bars indicate 20 μm. (a) Representative immunofluorescent pictures show the relationship between Rab14 and GLUT4 muscle fibers in Wistar rats: (a(A1–A4)) untreated; (a(B1–B4)) with SZT-induced diabetes; (a(C1–C4)) with SZT-induced diabetes and treated with TOL1, (a(D1–D4)) with TOL2, and (a(E1–E4)) with TOL3. (b) GLUT-Rab14 colocalization was assessed in the area of interest (0.014 mm²/4 μm slice × 3 slices/rat × 6 rats/group) by calculating the Pearson correlation coefficient using the JACoP plugin on ImageJ. Values are expressed as mean ± SD. One-way ANOVA followed by the post hoc Scheffé test: ** p < 0.01.