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. 2020 Dec 4;21(23):9261. doi: 10.3390/ijms21239261

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TAN blocks PMA induced hypoxia-inducible factor 1-alpha (HIF-1α) and nuclear factor kappa-light-chain-enhancer of activated b cells (NF-κB) inflammatory crosstalk. (A) Concept building diagram representing the interaction and crosstalk between HIF-1α and NF-κB after PMA challenge on mice ears, (B) PKCα expression on mice ear tissues evaluated by immunohistochemical analysis, (C) NF-κB-p65 levels evaluated by immunohistochemical analysis, (D) HIF-1α evaluated by immunohistochemical analysis, (E) Western blotting analysis cytoplasmic HIF-1α and NF-κB pathway markers evaluated from ear tissue homogenates. Scale bar (100 μM). Magnification = 200×. Statistical significance analysis was carried out through a one-way analysis of variance (ANOVA) prism. * p < 0.05, ** p < 0.01, *** p < 0.001 and ns (non-significant).