Table 2.

Summary of analyzed publications highlighting the tumor suppressor role of autophagy.

Publication Title	Proposed Molecular Mechanism for Sustaining the Tumor Suppressor Role of Autophagy	Reference
Autophagic cell death: the story of a misnomer	Autophagic cell death	[94]
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy	Autophagic cell death	[95]
Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death	Autophagic cell death	[45]
Autophagy mediates the mitotic senescence transition	Autophagic senescence	[96]
The dynamic nature of autophagy in cancer	Autophagic senescence	[97]
Cancer-related inflammation	Inflammation downregulation	[98]
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis	Inflammation downregulation	[99]
The double-edged sword of autophagy modulation in cancer	Inflammation downregulation	[74]
The Roles of Autophagy in Cancer.	Inflammation downregulation	[100]
Autophagy in immunity and inflammation	Inflammation downregulation	[101]
The Atg5–Atg12 conjugate associates with innate antiviral immune responses.	Inflammation downregulation	[102]
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production	Inflammation downregulation	[103]
Autophagy in mammalian development and differentiation	Inflammation downregulation	[7]
Autophagy in health and disease: A comprehensive review.	Inflammation downregulation	[104]
Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1 phenotypes in intestine	Inflammation downregulation	[105]
Reactive species: a cell damaging rout assisting to chemical carcinogens	Oxidative stress and genome instability	[106]
Mitochondrial gateways to cancer	Oxidative stress and genome instability	[107]
Autophagy suppresses tumor progression by limiting chromosomal instability	Oxidative stress and genome instability	[108]
Oncosuppressive functions of autophagy	Oxidative stress and genome instability	[109]
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1	Oxidative stress and genome instability	[110]
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62	Oxidative stress and genome instability	[111]