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. 2020 Dec 7;21(23):9325. doi: 10.3390/ijms21239325

Table 3.

Summary of analyzed publications highlighting the tumor growth promoter role of autophagy.

Publication Title Proposed Molecular Mechanism Reference
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Beclin-1 dependent regulation [99]
The double-edged sword of autophagy modulation in cancer. Stress tolerance increase [74]
The Roles of Autophagy in Cancer. Inflammation downregulation [100]
Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing P53-mediated apoptosis in hepatocellular carcinoma Ras activation [88]
Autophagy suppresses tumor progression by limiting chromosomal instability Ras activation [108]
Autophagy opposes P53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer P53 suppression [112]