Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 7;21(23):9310. doi: 10.3390/ijms21239310

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The role of β-arrestin1 (ARRB1) in regulating self-renewal and progression of myeloproliferative neoplasms. (a) ARRB1 promotes p300-SP1 interaction and SP1 mediated transcription of human telomerase reverse transcriptase (hTERT). Thus, ARRB1 is important for telomerase activity preventing the onset of cellular senescence in leukemia stem cells (LSCs). (b) ARRB1 facilitates enhancer of zeste homologue 2 (EZH2)-mediated acetylation of BCR/ABL histone H4, promoting progression of chronic myeloid leukemia. (c) ARRB1 facilitates the DNMT1-mediated methylation of the PTEN promoter region, promoting epigenetic silencing of PTEN and generation of leukemia stem cells in B-lineage acute lymphoblastic leukemia.