Figure 2.

Differential abundance of the gut microbiota per unit increase in rheumatoid arthritis PRS in TwinsUK participants

Positive log-fold change of taxa indicates a positive association with the rheumatoid arthritis PRS. Prevotella_7 was the strongest association, and positively associated with the rheumatoid arthritis PRS (q<1 × 10⁻⁷). Because of the scale and comparative difference in log-fold change in Prevotella, this taxon was excluded (B) to allow visualisation of the three other associations. Other taxa associations within the gut microbiota were Ruminococcaceae_UCG-14 (q=0·045), Rikenella (q=0·018), and Shigella (q=0·018). PRS=polygenic risk score.