Figure 4.

Differential abundance of the gut microbiota in HLA-DRB1 shared epitope-positive participants, compared with shared epitope-negative controls in the SCREEN-RA cohort

In all participants, Prevotella_7 showed the most substantial positive log-fold change of 5 (q=0·0348). Other genuses that showed lower but significant positive log-fold associations were Veillonella (q=0·035), Streptococcus (q=0·035), Ruminococcaceae UBA1819 (q=0·035), and Coprobacter (q=0·0020). In participants without symptoms associated with rheumatoid arthritis (excluding tender or swollen joints; grey shading), Prevotella_7 solely remained positively associated with shared epitope positivity (q=0·0011).