Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 30;21(23):9144. doi: 10.3390/ijms21239144

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Leptin induced sympathetic nervous system (SNS) signaling at β2A-receptors in osteoblasts inhibits the Insulin-OCN-Feed-Forward-Loop by causing an increase in ESP gene expression and therefore osteoblast testicular tyrosinphosphatase (OST-PTP) synthesis. OST-PTP in turn dephosphorylates the insulin receptor as well as FoxO-1leading to missing Runt-related transcription factor 2 (RUNX) stimulation and Gla-OCN production as well as the disinhibition of OPG synthesis followed by a decrease of ostoeclast activation and pH-dependent Glu-OCN release from the ECM [11,13,16,23,24,25].