Fig 2.

Different models for interaction of longevity and frailty. (a) In usual survivor longevity associated protection conferred by Geroprotector, including longevity factors (green) is less and accumulation of insults (red) leads to decrease in healthspan as well as lead to disabilities, frailty, and comorbidities finally leading to death. (b) In long-lived healthy individual have more Geroprotectors acting throughout life preventing insults as well as increasing stretch of healthspan as well as life span. Frailty and other comorbidities are confined to small time span. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)”