Table 1.

Potential S‐sulphydration targets relevant to macrophage regulation

Potential target	Modification site	Major cell types	Biological consequence	Reference
P65	Cys38	Macrophage	Inhibiting NF‐κB activity	33
c‐Jun	Cys269	Macrophage	Attenuating inflammasome activation and IL‐1β production	34
Keap1	Cys151, Cys226, Cys613	Fibroblast	Dissociation of Keap1‐Nrf2 complex; antioxidative response	29, 30
PTP1B	Cys215	293T cell	Alleviating ER stress	31
PPARγ	Cys139	Adipocyte	Enhancing DNA binding activity of PPARγ, increasing lipid metabolism	24
NFYB	Cys105	Regulatory T cell	Promoting the transcription of Tet1/2	20, 32

Keap1, Kelch‐like ECH‐associated protein 1; NFYB, nuclear transcription factor Y subunit beta; PTP1B, protein tyrosine phosphatase 1B; Tet, tet methylcytosine dioxygenase 2.